Some Biochemical and Haematological Effects of Garlic (Allium sativum) Ginger (Zingiber officiale) and extracts in rats

Eze Ejike Daniel

Abstract


Garlic and ginger have been used as a dietary agent through-out the world. The present study evaluated some biochemical and haematological effects of Ginger (Zingiber officiale) and Garlic (Allium sativum) extracts in rats. To achieve this, thirty five albino Wistar rats were used. They were divided into the following groups as follows: Group 1: Served as control and were administered with 1ml of distilled water, Group 2: Received 20mg/kg b w of garlic, Group 3: Received 40mg/kg b w of garlic, Group 4: Received 20mg/kg b w of ginger, Group 5: Received 40mg/kg b w of ginger, Group 6: Received garlic 10mg and ginger 10mg/kg b w Group 7: Received garlic 20mg and ginger 20mg/kg b w. All treatment is by gavage orally and lasted for a period of 28 days. After the last day of treatment, blood samples were collected for determination of biochemical and haematological parameters. The result showed a significantly decreased (p<0.05) serum sodium level and significantly elevated (p<0.05) serum potassium level in garlic and ginger extract treated groups when compared to the control group. In respect to serum chloride ion only 20 and 40mg/kg bw of garlic showed a significant effect (p<0.05) when compared to control group. There was statistically significant reduction (p<0.05) on serum levels of both ionized and total calcium in the extract treated groups when compared to the control group. There was a statistically significant reduction (p<0.05) on packed cell volume and haemoglobin concentration in garlic and ginger extract treated groups when compared to control group. However, the red cell count was significantly elevated (p<0.05) in the groups that received garlic and ginger extract when compared to the control group. There was a significant difference (p<0.05) in the groups that received 20 mg/kg bw of ginger extract and its combination with garlic at various doses for total white blood cell count and 40 mg/kg bw of ginger and its combination for neutrophils count when compared to control group. There was a significant difference (p<0.05) in the animals administered with 40 mg/kg bw of garlic and its combination for lymphocyte and monocyte count when compared to control group. In conclusion, administration of garlic and ginger as well as its combination to animals significantly alter the serum electrolytes and decreased the packed cell volume and haemoglobin concentration with an elevated red cell count.

Keywords


Garlic; ginger; rats; alanine aminotransferase; aspartate aminotransferase; red blood cell ; leucocytes

Full Text:

PDF

Refbacks

  • There are currently no refbacks.


Creative Commons License
This work is licensed under a Creative Commons Attribution 3.0 License.

JOS ©: World Science Publisher United States