Synthesis of New D-xylose Derivatives and study the antimicrobial effect

mohammad alsaidy

Abstract


D - xylose was converted into new allylic furanosyl and pyranosyl glycosides by applying two different reaction conditions. The glycosides then were treated with sodium azide to get triazoline compounds via a 1,3-dipolar cycloaddition. The new glycosides and the triazoline the synthesized derivatives were screened for in vitro antimicrobial activity against tow human pathogenic bacteria(S.aureus , E.coli) and one fungal (Candida albicans)  the pathogens. The study revealed that the triazoline derivatives exhibit promising antibacterial and antifungal activities. The triazoline derivatives were found to be more effective against the fungal strains than those of the bacterial pathogens. However, a good number of  derivatives glycosides exhibited better antimicrobial activity than the standard antibiotics . Compounds were identified by I.R,1H – and 13C – NMR. spectroscopy.

Keywords


D- xylose, derivatives, glycosides, antimicrobial activity; inhibition; pathogens

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