The Bioprotective Efficacy of Hibiscus sabdariffa (Roselle), Moringa oleifera (Moringa) Zingiber officinale (Ginger) and Telfairia occidentalis (‘Ugwu’) in the Livers and Kidneys of Rattus norvegicus (Albino rats) Exposed to Cement dust



Roselle, moringa, ginger and ‘ugwu’ are food plants eaten as vegetables or spices in most communities in Nigeria. The bioprotective efficacy of the extracts of these plants was assessed in the livers and kidneys of albino rats exposed to cement dust around a polluted environment. Six groups of rats comprising 18 rats each were exposed to cement dust at 200 m from a cement factory in Southwest, Nigeria. The control group was administered distilled water, while the test groups were fed with 400 mg kg-1 ethanolic extracts of roselle, moringa, ginger, ‘ugwu’ and a mixture of the extracts of the plants for 180 days. They were subsequently sacrificed for the histopathological studies of the harvested livers and kidneys. The organs of the control rats group presented abnormal cellular architecture, vascular congestion and inflammation whereas normal cellular pattern, slight inflammation and no vascular congestion were evident in the group that received the mixture. However, the organs of the rats administered the extracts of roselle, moringa, ginger and ‘ugwu’ respectively, presented normal and moderate to severe conditions of the histopathological abnormalities observed in the control group. These results suggest that these food plants could play a role in health care delivery, through bioprotection of the livers and kidneys of inhabitants of polluted environments, and may also be useful in ameliorating the effects of occupational hazards.


cement dust, bioprotective, extract, histopathology, ameliorative

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