Isonotatic acid inhibits the growth of murine methylcholanthrene induced epidermoid blastoma cells in vitro
We test the effects of Isonotatic acid, secondary metabolite of the lichen Usnea arguta, on the growth of murine methylcholanthrene induced epidermoid blastoma cells in vitro. We find that Isonotatic acid is a potent inhibitor of growth. We also find that Isonotatic acid increases sensitivity of cells to radiation, and this effect is significant at a radiation intensity lower than the standard intensity of cancer radiotherapy. On the basis of this study, Isonotatic acid shows promise for combined-modality cancer treatment.
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