Cardio-protective Effects of Aqueous Extracts of Garlic and Ginger in Laboratory Animals

Eze Ejike Daniel

Abstract


Garlic and ginger have attracted particular attention of modern medicine because of its wide spread use around the world and the cherished belief that it helps to maintain good health by warding off illness and providing more vigor. The study investigated the cardio-protective property of Garlic (Allium sativum) and Ginger (Zingiber officiale) extracts in laboratory animals. Animals of both sexes were assigned  into the following: Group 1: Served as control and were administered with 1ml of distilled water, Group 2: Received 20mg/kg b w of garlic, Group 3: Received 40mg/kg b w of garlic, Group 4: Received 20mg/kg b w of ginger, Group 5: Received 40mg/kg b w of ginger, Group 6: Received garlic 10mg and ginger 10mg/kg b w Group 7: Received garlic 20mg and ginger 20mg/kg b w. All administration was given orally once daily for a duration of four (4) weeks. Animals were euthanized after the last day of extract treatment and blood samples were collected and serum separated for lipid profile assay. The results obtained in the study showed a statistically significant reduction (p<0.05) of serum total cholesterol, triglyceride and low density lipoprotein levels at all single and combined doses of the extract administered to the animals when compared to the control group. However, the extract at single and combined doses significantly elevated (p<0.05) serum high density lipoprotein level in the treated animals when compared the control group. The administration of the extract especially at the combined doses produced a reduction on the rate and force of contraction respectively when compared with the baseline line control level The interaction between the extract and the standard drug (adrenaline) revealed that the extract completely blocked the action of adrenaline when co-administered, hence reducing both the rate and force of contraction . In conclusion, the findings suggest that the extract as well as its combination improves lipid profile in the animals and the cardio-protective effect of garlic and ginger was linked to the decrease on the rate and force of contraction of isolated perfuse heart studied.

 


Keywords


Garlic; ginger; high-density lipoprotein; isolated perfuse heart; total cholesterol; triglyceride; low-density lipoprotein

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