Ameliorative Effect of Vitamin C on Serum Liver Enzymes in Lead-Induced Toxicity in Wistar Rats

Eze Ejike Daniel


This study was carried out to investigate the ameliorative effect of vitamin C on serum liver enzymes in lead-induced toxicity in wistar rats. Twenty (20) male rats were used for the experiment. Group 1 was administered distilled water , Group II was administered vitamin C 100mg/kg b w, Group III was administered lead 250mg/kg b w, Group IV was administered vitamin  (100mg/kg) and 30minutes later was administered lead (250mg/kg). Animals were exposed to treatments once daily for 28 days. After the last day of treatment animals were sacrificed and blood samples collected by cardiac puncture and serum separated for serum liver enzymes analysis. Results obtained in this present study revealed no statistically significant change (p>0.05) on the weight of the liver tissue treated with lead only and lead and vitamin C treated groups when compared to normal saline and vitamin C treated group. The result also showed a significantly reduced serum concentration of aspartate aminotransferase, alanine transferase  and alkaline phosphatise in groups treated with lead only when compared to normal and vitamin C treated only. However, co-administration of lead and vitamin C resulted to a significantly elevation of these enzymes. It is concluded that the decrease in ALT, AST and ALP were ameliorated by the administration of vitamin C which may be due to its antioxidant properties


Alanine aminotransferase; aspartate amino transferase; alkaline phosphatise; lead; vitamin C

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