Locating the Focus of Panic Disorder Patients via Magnetic Resonance Spectroscopy

Preetha Sosanna Phillips


This study focused on the analysis of the concentration of the metabolite ratios in relation to panic disorder (PD) using magnetic resonance spectroscopy (MRS). A high concentration of metabolites in the brain may play a significant role in panic disorder. The abnormalities in brain chemicals and concentration ratios of different metabolites may be a distinctive factor between PD patients and individuals without the disorder. The method reported in this paper could prove to be an effective tool in diagnosing panic disorder.

The data was collected from 49 patients. For each one the data was put in a five dimensional matrix to organize the data. The significant metabolites that were analyzed in the data were N-acetyl aspirate (NAA), choline (CHO), and creatine (CRE). The ratios that were analyzed were CHO2NAA, CHO22CRE, and NAA2CRE.

The results of the study indicate that there are distinctive metabolite differences between PD patients and the normal controls. The focus of panic disorder patients was located in the spectrum of CHO2NAA. By determining the CHO2NAA value in the brain, doctors can diagnose patients with greater ease. Future research is necessary in order to clearly understand the effects of the concentration of metabolites on panic disorder. A further understanding of the different metabolite concentrations will not only allow doctors to diagnose patients with panic disorder easily, but also may help contribute to creating more effective treatments.


MRS; Panic Disorder; MRSI; assist diagnose;classification tree

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