Uric Acid Inhibition Activity of Annona muricata L Leave Extract in Hyperuricemia induced Wistar Rat

Putra Manuaba


This research aims to find a cure of gout, base on the utilization of Annona muricata. The research was started with descriptive study to explore active components of Annona muricata leaf and followed by an experimental study to investigate uric acid inhibition activity of the leaf extract in hyperuricemia induced wistar rat. We observed three dominant components, i.e. 2,3-dihidrobenzofuran; 3-ethoxy-1,4,4a,5,6,7,8,8a-octahydroisoquinoline;  2-cyclohexen-1-one, 4-hydroxy-3,5,6-trimethyl-4-(3-oxo-1-butenyl) which were probably active to inhibit uric acid formation in hyperuricemic induced wistar rat. In this study, n-buthnol was applied for partitioning the relatively pure compound. The n-buthanol extract obtained was then applied to cure hyperuricemic rat induced by a mixture of chicken livers and Gnetum gnemon a high purine diet. It was obtained, that the highest extract dose of  400 mg/kgBW was able to inhibit the formation of uric acid in hyperuricemic rat. It can be concluded that Annona muricata leaf extracted with n-buthanol in a dose of 400 mg/kg BW has an ability to inhibit further formation uric acid in hyperuricemic rat. Therefore, this natural plant is potent to develop for hyperuricemic medicine.




Keywords: gout, Annona muricata, hyperuricemic rat, active components.

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